Safety and drug survival of methotrexate versus tioguanine after failure of conventional thiopurines in patients with Crohn's disease

Keyphrases

• Crohn's Disease 100%
• Methotrexate 100%
• Thiopurines 100%
• Drug Survival 100%
• Tioguanine 100%
• Adverse Events 31%
• Subsequent Therapy 10%
• Biological Therapy 10%
• Biological Treatment 10%
• Serious Adverse Events 10%
• Thiopurine Therapy 10%
• Dutch 5%
• High Risk 5%
• Treatment Options 5%
• Liver Fibrosis 5%
• Median Time 5%
• Tolerability 5%
• Monotherapy 5%
• Nodular Regenerative Hyperplasia 5%
• Liver Cirrhosis 5%
• Treatment Failure 5%
• Follow-up Interval 5%
• Nausea 5%
• Retrospective multicenter Study 5%
• Treatment Discontinuation 5%
• Discontinuation Rate 5%
• Elevated Liver Enzymes 5%
• Therapy Discontinuation 5%
• Abdominal Pain 5%
• Starting Treatment 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Crohn's Disease 100%
• Methotrexate 100%
• Tioguanine 100%
• Mercaptopurine 100%
• Adverse Event 42%
• Infection 5%
• Monotherapy 5%
• Tolerability 5%
• Liver Cirrhosis 5%
• Liver Fibrosis 5%
• Hyperplasia 5%
• Nausea 5%
• Hypertransaminasemia 5%
• Abdominal Pain 5%