SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

HCA Lung Biological, Waradon Sungnak*, Ni Huang, Christophe Becavin, Marijn Berg, Rachel Queen, Monika Litvinukova, Carlos Talavera-Lopez, Henrike Maatz, Daniel Reichart, Fotios Sampaziotis, Kaylee B. Worlock, Masahiro Yoshida, Josephine L. Barnes, Martijn Nawijn

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

1457 Citaten (Scopus)


We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at

Originele taal-2English
Pagina's (van-tot)681-687
Aantal pagina's14
TijdschriftNature Medicine
Nummer van het tijdschrift5
StatusPublished - 1-mei-2020

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