Self-Assembly Can Direct Dynamic Covalent Bond Formation Towards Diversity or Specificity

David Komaromy, Marc C A Stuart, Guillermo Monréal Santiago, Meniz Tezcan, Victor V Krasnikov, Sijbren Otto

OnderzoeksoutputAcademicpeer review

37 Citaten (Scopus)
269 Downloads (Pure)


With the advent of reversible covalent chemistry the study of the interplay between covalent bond formation and non-covalent interactions has become increasingly relevant. Here we report that the interplay between reversible disulfide chemistry and self-assembly can give rise either to molecular diversity, i.e. the emergence of a unprecedentedly large range of macrocycles or to molecular specificity, i.e. the autocatalytic emergence of a single species. The two phenomena are the result of two different modes of self-assembly, demonstrating that control over self-assembly pathways can enable control over covalent bond formation.

Originele taal-2English
Pagina's (van-tot)6234-6241
TijdschriftJournal of the American Chemical Society
Nummer van het tijdschrift17
Vroegere onlinedatum11-apr-2017
StatusPublished - 3-mei-2017

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