Sequential uniform designs for fingerprints development of Ginkgo biloba extracts by capillary electrophoresis

Yi Bing Ji, Goedele Alaerts, Cheng Jian Xu, Yu Zhu Hu, Yvan Vander Heyden*

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    50 Citaten (Scopus)


    A sequential procedure for the method of development of fingerprints based on a uniform design approach has been described in this paper. The sequential uniform design is used to reach the global optimum for a separation. The procedure is illustrated through developing the fingerprint of a Ginkgo biloba extract by capillary electrophoresis (CE) with diode array detection (DAD). The local overlap index (LOVI) is proposed as a criterion to evaluate the separation quality of two-dimensional hyphenated data in the optimization process. The successful application of the described techniques, including a sequential procedure, the CE-DAD hyphenated method and the LOVI criterion, shows their practicality in the fingerprint development of herbal medicines. However, some critical remarks on their use can also be made.

    Originele taal-2English
    Pagina's (van-tot)273-281
    Aantal pagina's9
    TijdschriftJournal of Chromatography A
    Nummer van het tijdschrift1-2
    StatusPublished - 22-sep-2006

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