TY - JOUR
T1 - Serous Tubal Intraepithelial Carcinoma After Neoadjuvant Chemotherapy
T2 - A Report of 2 Cases
AU - Stroot, Iris A S
AU - Smit, Leonie
AU - de Bock, Geertruida H
AU - Wagner, Marise M
AU - Jalving, Mathilde
AU - van Kempen, Léon C L T
AU - Bart, Joost
AU - Mourits, Marian J E
N1 - Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.
PY - 2024/8/22
Y1 - 2024/8/22
N2 - Serous tubal intraepithelial carcinoma (STIC) is regarded as the origin of most high-grade serous carcinomas (HGSC). After a diagnosis of isolated STIC, risk of developing HGSC is substantial. Since surveillance cannot detect HGSC in time to cure the disease, there is no consensus on the optimal treatment after a diagnosis of isolated STIC, but chemotherapy is considered one of the possible strategies. In this case report, we describe 2 women with advanced-stage HGSC treated with 3 cycles of neoadjuvant chemotherapy followed by interval debulking surgery. In both women, histopathological examination showed a complete histopathological tumor response, but a vital STIC was found in both cases. The 2 cases presented here indicate that STICs may not respond to chemotherapy. Further research focused on the underlying biology and chemosensitivity of STIC, as well as the effectiveness of treatment to prevent HGSC in case of isolated STIC, is needed.
AB - Serous tubal intraepithelial carcinoma (STIC) is regarded as the origin of most high-grade serous carcinomas (HGSC). After a diagnosis of isolated STIC, risk of developing HGSC is substantial. Since surveillance cannot detect HGSC in time to cure the disease, there is no consensus on the optimal treatment after a diagnosis of isolated STIC, but chemotherapy is considered one of the possible strategies. In this case report, we describe 2 women with advanced-stage HGSC treated with 3 cycles of neoadjuvant chemotherapy followed by interval debulking surgery. In both women, histopathological examination showed a complete histopathological tumor response, but a vital STIC was found in both cases. The 2 cases presented here indicate that STICs may not respond to chemotherapy. Further research focused on the underlying biology and chemosensitivity of STIC, as well as the effectiveness of treatment to prevent HGSC in case of isolated STIC, is needed.
U2 - 10.1097/PGP.0000000000001045
DO - 10.1097/PGP.0000000000001045
M3 - Article
C2 - 39173127
SN - 0277-1691
JO - International journal of gynecological pathology
JF - International journal of gynecological pathology
ER -