Serum calcification propensity is associated with HbA1c in type 2 diabetes mellitus

Rik Mencke, Amarens van der Vaart, Andreas Pasch, Geert Harms, Femke Waanders, Henk J G Bilo, Harry van Goor, Jan-Luuk Hillebrands, Peter R van Dijk*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

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Introduction Serum calcification propensity is emerging as an independent predictor for cardiovascular outcomes in high-risk populations. Calcification propensity can be monitored by the maturation time of calciprotein particles in serum (T-50 test). A low T-50 value is an independent determinant of cardiovascular morbidity and mortality in various populations. Aim was to investigate the T-50 and its relationship to type 2 diabetes mellitus.

Research design and methods Using nephelometry, serum T-50 was cross-sectionally measured in 932 stable patients with type 2 diabetes mellitus (55% male) with a median age of 66 (62-75) years, diabetes duration of 6.5 (3.0-10.2) years and hemoglobin A1c (HbA1c) of 49 (44-54) mmol/mol.

Results Serum T-50 was normally distributed with a mean value of 261 +/- 66 min. In linear regression, serum T-50 was lower in women and current smokers. A lower T-50 value was found in patients with a higher HbA1c or higher systolic blood pressure, insulin users and patients with a longer history of diabetes. The association with HbA1c was independent of other determinants in multivariable analysis. There was no association between T-50 and previous macrovascular events or the presence of microvascular disease.

Conclusions Serum calcification propensity is independently associated with glycemic control, suggesting that a lower HbA1c may be associated with better cardiovascular outcomes. Retrospective analysis could not establish an association between a history of macrovascular events and T-50, and prospective studies will have to be performed to address this hypothesis.

Originele taal-2English
Artikelnummer002016
Aantal pagina's7
TijdschriftBMJ Open Diabetes Research & Care
Volume9
Nummer van het tijdschrift1
DOI's
StatusPublished - feb-2021

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