Serum free thiols in type 2 diabetes mellitus: A prospective study

Emmelien E M Schillern, Andreas Pasch, Martin Feelisch, Femke Waanders, Steven H Hendriks, Rik Mencke, Geert Harms, Klaas H Groenier, Henk J G Bilo, Jan-Luuk Hillebrands, Harry van Goor, Peter R van Dijk

OnderzoeksoutputAcademicpeer review

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Aims: Oxidative stress is a driver in the development of type 2 diabetes (T2DM) complications. As thiols (R-SH) are oxidized by reactive oxygen and sulfur species, circulating concentrations may directly reflect systemic redox status. We hypothesized that high serum R-SH concentrations are a reflection of a favourable redox status and may therefore positively associate with disease status.

Methods: R-SH were measured in serum of 943 T2DM outpatients (55% males, 65 years and HbA1c of 6.7% (50 mmol/mol)) with a follow-up period of 1.2 years.

Results: In the highest R-SH tertile patients were younger, more often men, had less microvascular complications, lower HbA1c and were more often treated nutritionally or with oral glucose-lowering drugs. Age-and sex adjusted hazard ratios for developing micro-, macro- or any complication plus death were 0.994, 0.992 and 0.993: even after adjustment for potential confounders. The Harrell's C statistic to predict microvascular complications or any complication plus death was higher in the models with R-SH than in those without R-SH.

Conclusions: Although R-SH concentrations were associated with a favourable disease status, it did not add to the predictive capacity for long-term complications. Based on the current data R-SH seems unsuitable as a prognostic marker in T2DM.

Originele taal-2English
Artikelnummer100182
Aantal pagina's6
TijdschriftJournal of clinical & translational endocrinology
Volume16
DOI's
StatusPublished - jun-2019

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