Severe comorbidity negatively influences prognosis in patients with oral and oropharyngeal cancer after surgical treatment with microvascular reconstruction

Pepijn A. Borggreven, Dirk J. Kuik, Johannes A. Langendijk, Patricia Doornaert, Remco de Bree, C. René Leemans

OnderzoeksoutputAcademicpeer review

28 Citaten (Scopus)


The aim of the study was to investigate the possible impact of comorbidity on survival of patients undergoing composite resection and microvascular reconstruction for oral/oropharyngeat cancer.

Patient, tumour and treatment data were recorded. Comorbidity was graded by the Adult Comorbidity Evaluation (ACE-27) test. Survival and statistics were calculated.

Comorbidity score ACE-27 grade >= 2 was present in 47% of patients, for ACE-27 grade 3 this was 13%. The median follow-up was 50 (3-87) months. Thirty-eight patients died, 32 developed a recurrence. Comorbidity score ACE-27 grade 3 turned out to be a clear predictor for overall survival (p <0.05). For ACE-27 grade 3 (n = 13) 5-years survival was 29%, for ACE-27 grade

Improved knowledge of the effect of comorbidity on survival may lead to better patient selection and counselling for major surgery and microvascular reconstruction. (c) 2004 Elsevier Ltd. All rights reserved.

Originele taal-2English
Pagina's (van-tot)358-364
Aantal pagina's7
TijdschriftOral Oncology
Nummer van het tijdschrift4
StatusPublished - apr-2005
Extern gepubliceerdJa

Citeer dit