Short and diverse route toward complex natural product-like macrocycles.

Barbara Beck, Gregor Larbig, Beatrice Mejat, Marina Magnin-Lachaux, Anne Picard, Eberhardt Herdtweck, Alexander Dömling

OnderzoeksoutputAcademicpeer review

108 Citaten (Scopus)


[reaction: see text] A general strategy toward macrocyclic compounds using multicomponent reaction (MCR) chemistry, e.g., Passerini and Ugi variants, and ring-closing metathesis (RCM) is introduced. The corresponding bifunctional isocyanides carboxylic acids bearing a terminal olefin are easy to prepare from the corresponding commercially available starting materials. Advantageously, this strategy allows fast access to a diverse conformational space of natural product-like macrocycles and could thus be of interest in the discovery of novel bioactive agents.
Originele taal-2English
Pagina's (van-tot)1047-1050
Aantal pagina's4
TijdschriftOrganic letters
Nummer van het tijdschrift7
StatusPublished - 2003

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