Shutting down the power supply for DNA repair in cancer cells

Marcel A. T. M. van Vugt

doi:10.1083/jcb.201701026

Shutting down the power supply for DNA repair in cancer cells

Marcel A. T. M. van Vugt^*

^*Corresponding author voor dit werk

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10 Citaten (Scopus)

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Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination-mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.

Originele taal-2	English
Pagina's (van-tot)	295-297
Aantal pagina's	3
Tijdschrift	The Journal of Cell Biology
Volume	216
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1083/jcb.201701026
Status	Published - feb.-2017

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10.1083/jcb.201701026Licentie: CC BY-NC-SA

Shutting down the power supply for DNA repair in cancer cellsFinal publisher's version, 1,1 MBLicentie: CC BY-NC-SA

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title = "Shutting down the power supply for DNA repair in cancer cells",

abstract = "Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination-mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.",

keywords = "PHOSPHOGLYCERATE MUTASE, STRESS, DAMAGE, G2",

author = "{van Vugt}, {Marcel A. T. M.}",

year = "2017",

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doi = "10.1083/jcb.201701026",

language = "English",

volume = "216",

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PY - 2017/2

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N2 - Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination-mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.

AB - Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination-mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.

KW - PHOSPHOGLYCERATE MUTASE

KW - STRESS

KW - DAMAGE

KW - G2

U2 - 10.1083/jcb.201701026

DO - 10.1083/jcb.201701026

M3 - Review article

SN - 0021-9525

VL - 216

SP - 295

EP - 297

JO - The Journal of Cell Biology

JF - The Journal of Cell Biology

IS - 2

ER -

Shutting down the power supply for DNA repair in cancer cells

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