Samenvatting
A novel class of compounds that contain a silatrane moiety attached to or incorporated within a nucleoside is described. These compounds are transition state analogues for phosphoryl transfer reactions and as such have potential antiviral and anticancer properties. The two-step synthesis of 3′-O-(trimethyl)silatranylthymidine (1) in 17% yield is reported. The aqueous half-life of 1 was determined to be 62 h by 1H NMR. The syntheses of three 2′,3′-protected-5′-O-silatranyladenosines in 25–55% yields are also described.
Originele taal-2 | English |
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Pagina's (van-tot) | 4979-4982 |
Aantal pagina's | 4 |
Tijdschrift | Tetrahedron Letters |
Volume | 42 |
Nummer van het tijdschrift | 30 |
DOI's | |
Status | Published - 23-jul.-2001 |
Extern gepubliceerd | Ja |