Simvastatin but not bezafibrate decreases plasma lipoprotein-associated phospholipase A(2) mass in type 2 diabetes mellitus: Relevance of high sensitive C-reactive protein, lipoprotein profile and low-density lipoprotein (LDL) electronegativity

Alexander Constantinides, Rindert de Vries, Jeroen J. J. van Leeuwen, Thomas Gautier, L. Joost van Pelt, Alexandros D. Tselepis, Laurent Lagrost, Robin P. F. Dullaart*

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    6 Citaten (Scopus)

    Samenvatting

    Objective: Plasma lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) levels predict incident cardiovascular disease, impacting Lp-PLA(2) as an emerging therapeutic target. We determined Lp-PLA(2) responses to statin and fibrate administration in type 2 diabetes mellitus, and assessed relationships of changes in Lp-PLA(2) with subclinical inflammation and lipoprotein characteristics.

    Methods: A placebo-controlled cross-over study (three 8-week treatment periods with simvastatin (40 mg daily), bezafibrate (400 mg daily) and their combination) was carried out in 14 male type 2 diabetic patients. Plasma Lp-PLA(2) mass was measured by turbidimetric immunoassay.

    Results: Plasma Lp-PLA(2) decreased (-21 +/- 4%) in response to simvastatin (p

    Conclusions: In type 2 diabetes mellitus, plasma Lp-PLA(2) is likely to be lowered by statin treatment only. Enhanced subclinical inflammation and more severe dyslipidemia may predict diminished LpPLA(2) responses during lipid lowering treatment, which in turn appear to be quantitatively dissociated from decreases in apolipoprotein B lipoproteins. Conventional lipid lowering treatment may be insufficient for optimal LpPLA(2) lowering in diabetes mellitus. (C) 2012 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

    Originele taal-2English
    Pagina's (van-tot)633-638
    Aantal pagina's6
    TijdschriftEuropean Journal of Internal Medicine
    Volume23
    Nummer van het tijdschrift7
    DOI's
    StatusPublished - okt-2012

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