Skin autofluorescence as a measure of tissue advanced glycation end products deposition is elevated in diabetic patients with peripheral artery disease

L.C. De Vos, D.J. Mulder, R.P.F. Dullaart, H.L. Lutgers, A.J. Smit, P.W. Kamphuisen, Johanna Westra, C.J. Zeebregts, J.D. Lefrandt

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Backgrounds and aims: Diabetes mellitus (DM) is an important risk factor for peripheral artery disease (PAD) and associated with a particularly poor prognosis in these patients. Increased glycemic and oxidative stress in DM enhance the accumulation of advanced glycation end products (AGEs), which play an important role in the development of atherosclerosis and cardiovascular (CV) disease. Skin autofluorescence (SAF) is a validated noninvasive method to measure tissue AGEs. Earlier, we showed that SAF is increased in DM, associated with vascular complications and predictive for mortality. However, accumulation of tissue AGEs in DM patients with PAD has not been studied. We aimed to study whether tissue AGEs are increased in DM patients with PAD and to establish the determinants of tissue AGEs deposition. Materials and methods: We performed a case control study. PAD was confirmed by angiography or duplex ultrasonography. CV risk factors and CV comorbidity (coronary artery disease [CAD], cerebrovascular disease [CVD], abdominal aortic aneurysm [AAA]) were assessed. Hypertension and hypercholesterolemia were defined as the use of blood pressure and lipid lowering drugs, respectively. SAF was measured with the AGE ReaderTM. Independent sample t-tests, Mann-Whitney-U tests, Chi-square tests, backward linear and logistic regression analysis were performed. Data are shown as mean ± standard deviation, median (Q1-Q3), or as number (%). Results: A total of 127 DM patients with PAD were compared with 127 DM patients without PAD, matched for age. Characteristics are shown in table 1. Patients with PAD had more CV risk factors, but a higher estimated glomerular filtration rate (eGFR). SAF was higher in diabetic patients with PAD compared to diabetic patients without PAD: 3.11 ± 0.69 versus 2.71 ± 0.68 arbitrary units, P
Originele taal-2English
Pagina's (van-tot)530
Aantal pagina's1
TijdschriftDiabetologia
Volume56
DOI's
StatusPublished - sep-2013
Evenement49th Annual Meeting of the European Association for the Study of Diabetes (EASD) - Barcelona, Spain
Duur: 23-sep-201327-sep-2013

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