In fMRI, any fluctuation of signal intensity, not recognized as a result of a specific task, is treated as noise. One source for "noise" is subject motion. Normally, motion effects are reduced by applying realignment. We investigate how apt a realignment procedure is in removing motion-related effects by comparing the distribution of the normnalized standard deviation of each voxel, NSD (=standard deviation/mean), before and after realignment.
We use data acquired from a simulation program developed previously. This program covers the effects of spin history, slice profiles, and motion in (f)MRI. We simulated inter-volume motion perpendicular to the slices of a digital, artificial head phantom, with and without spin history. In all cases, fluctuations in signal intensity were reduced after standard realignment. This effect was. strongest when no spin history was present. Hence, spin history has a marked effect on the "noise".
The spatial distribution of NSD showed similarities to the structures of the. brain. This indicates that (residual) motion effects were largest at the transitions between tissues. Possibly, the spatial distribution of NSD can provide a (independent) tool to investigate brain structure. Furthermore, the method presented can be used to qualitatively compare different "noise" reduction steps in fMRI data analysis.
|Titel||MEDICAL IMAGING 2003: PHYSICS OF MEDICAL IMAGING, PTS 1 AND 2|
|Redacteuren||MK Yaffe, LE Antonuk|
|Plaats van productie||BELLINGHAM|
|Uitgeverij||SPIE - INT SOC OPTICAL ENGINEERING|
|ISBN van geprinte versie||0-8194-4831-1|
|Status||Published - 2003|
|Evenement||Medical Imaging 2003 Conference - , Canada|
Duur: 17-feb-2003 → 20-feb-2003
|Naam||PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE)|
|Uitgeverij||SPIE-INT SOC OPTICAL ENGINEERING|
|ISSN van geprinte versie||0277-786X|
|Other||Medical Imaging 2003 Conference|
|Periode||17/02/2003 → 20/02/2003|