Spinocerebellar ataxia: miRNAs expose biological pathways underlying pervasive Purkinje cell degeneration

Rogier van der Stijl, Sebo Withoff, Dineke S. Verbeek*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articleAcademicpeer review

3 Citaten (Scopus)

Samenvatting

Recent work has demonstrated the importance of miRNAs in the pathogenesis of various brain disorders including the neurodegenerative disorder spinocerebellar ataxia (SCA). This review focuses on the role of miRNAs in the shared pathogenesis of the different SCA types. We examine the novel findings of a recent cell-type-specific RNA sequencing study in mouse brain and discuss how the identification of Purkinje-cell-enriched miRNAs highlights biological pathways that expose the mechanisms behind pervasive Purkinje cell degeneration in SCA. These key pathways are likely to contain targets for therapeutic development and represent potential candidate genes for genetically unsolved SCAs.

Originele taal-2English
Pagina's (van-tot)148-158
Aantal pagina's11
TijdschriftNeurobiology of Disease
Volume108
DOI's
StatusPublished - dec-2017

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