Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma

Jeroen E van Schaik; Anna C Muller Kobold; Bernard F A M van der Laan; Bert van der Vegt; Bettien M van Hemel; Boudewijn E C Plaat

doi:10.1002/hed.25733

Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma

Jeroen E van Schaik, Anna C Muller Kobold, Bernard F A M van der Laan, Bert van der Vegt, Bettien M van Hemel, Boudewijn E C Plaat

Onderzoeksoutput › Academic › peer review

5 Citaten (Scopus)

182 Downloads (Pure)

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BACKGROUND: The purpose of this study was to determine the additional diagnostic value of squamous cell carcinoma antigen (SCC-Ag) in cervical lymph node fine needle aspiration (FNA) samples for the detection of regional metastases of head and neck squamous cell carcinoma (HNSCC).

METHODS: In 149 FNA samples of 114 patients, SCC-Ag concentration was retrospectively analyzed and associated with diagnosis to establish a cutoff concentration in relation to sensitivity and specificity of HNSCC detection.

RESULTS: SCC-Ag was elevated in lymph nodes from patients with HNSCC compared to lymph nodes from other patients (P < 0.01). With 0.3 μg/L as the cutoff concentration, SCC-Ag has 96% sensitivity for detecting HNSCC.

CONCLUSIONS: SCC-Ag in FNA is a reliable test for detecting HNSCC in cervical lymph nodes.

Originele taal-2	English
Pagina's (van-tot)	2561-2565
Aantal pagina's	5
Tijdschrift	Head and Neck: Journal of the Sciences and Specialties of the Head and Neck
Volume	41
Nummer van het tijdschrift	8
Vroegere onlinedatum	4-mrt.-2019
DOI's	https://doi.org/10.1002/hed.25733
Status	Published - aug.-2019

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10.1002/hed.25733Licentie: CC BY-NC-ND

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van Schaik, J. E., Muller Kobold, A. C., van der Laan, B. F. A. M., van der Vegt, B., van Hemel, B. M., & Plaat, B. E. C. (2019). Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma. Head and Neck: Journal of the Sciences and Specialties of the Head and Neck, 41(8), 2561-2565. https://doi.org/10.1002/hed.25733

van Schaik, Jeroen E ; Muller Kobold, Anna C ; van der Laan, Bernard F A M et al. / Squamous cell carcinoma antigen concentration in fine needle aspiration samples : A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma. In: Head and Neck: Journal of the Sciences and Specialties of the Head and Neck. 2019 ; Vol. 41, Nr. 8. blz. 2561-2565.

@article{21cd0096b6a341f583d94a85892b8319,

title = "Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma",

abstract = "BACKGROUND: The purpose of this study was to determine the additional diagnostic value of squamous cell carcinoma antigen (SCC-Ag) in cervical lymph node fine needle aspiration (FNA) samples for the detection of regional metastases of head and neck squamous cell carcinoma (HNSCC).METHODS: In 149 FNA samples of 114 patients, SCC-Ag concentration was retrospectively analyzed and associated with diagnosis to establish a cutoff concentration in relation to sensitivity and specificity of HNSCC detection.RESULTS: SCC-Ag was elevated in lymph nodes from patients with HNSCC compared to lymph nodes from other patients (P < 0.01). With 0.3 μg/L as the cutoff concentration, SCC-Ag has 96% sensitivity for detecting HNSCC.CONCLUSIONS: SCC-Ag in FNA is a reliable test for detecting HNSCC in cervical lymph nodes.",

keywords = "FNA, HNSCC, lymph node, SCC-Ag, tumor marker, CANCER, MARKERS, SIZE",

author = "{van Schaik}, {Jeroen E} and {Muller Kobold}, {Anna C} and {van der Laan}, {Bernard F A M} and {van der Vegt}, Bert and {van Hemel}, {Bettien M} and Plaat, {Boudewijn E C}",

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year = "2019",

month = aug,

doi = "10.1002/hed.25733",

language = "English",

volume = "41",

pages = "2561--2565",

journal = "Head and Neck: Journal of the Sciences and Specialties of the Head and Neck",

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van Schaik, JE , Muller Kobold, AC , van der Laan, BFAM , van der Vegt, B , van Hemel, BM & Plaat, BEC 2019, 'Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma', Head and Neck: Journal of the Sciences and Specialties of the Head and Neck, vol. 41, nr. 8, blz. 2561-2565. https://doi.org/10.1002/hed.25733

Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma. / van Schaik, Jeroen E ; Muller Kobold, Anna C ; van der Laan, Bernard F A M et al.
In: Head and Neck: Journal of the Sciences and Specialties of the Head and Neck, Vol. 41, Nr. 8, 08.2019, blz. 2561-2565.

Onderzoeksoutput › Academic › peer review

TY - JOUR

T1 - Squamous cell carcinoma antigen concentration in fine needle aspiration samples

T2 - A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma

AU - van Schaik, Jeroen E

AU - Muller Kobold, Anna C

AU - van der Laan, Bernard F A M

AU - van der Vegt, Bert

AU - van Hemel, Bettien M

AU - Plaat, Boudewijn E C

PY - 2019/8

Y1 - 2019/8

N2 - BACKGROUND: The purpose of this study was to determine the additional diagnostic value of squamous cell carcinoma antigen (SCC-Ag) in cervical lymph node fine needle aspiration (FNA) samples for the detection of regional metastases of head and neck squamous cell carcinoma (HNSCC).METHODS: In 149 FNA samples of 114 patients, SCC-Ag concentration was retrospectively analyzed and associated with diagnosis to establish a cutoff concentration in relation to sensitivity and specificity of HNSCC detection.RESULTS: SCC-Ag was elevated in lymph nodes from patients with HNSCC compared to lymph nodes from other patients (P < 0.01). With 0.3 μg/L as the cutoff concentration, SCC-Ag has 96% sensitivity for detecting HNSCC.CONCLUSIONS: SCC-Ag in FNA is a reliable test for detecting HNSCC in cervical lymph nodes.

AB - BACKGROUND: The purpose of this study was to determine the additional diagnostic value of squamous cell carcinoma antigen (SCC-Ag) in cervical lymph node fine needle aspiration (FNA) samples for the detection of regional metastases of head and neck squamous cell carcinoma (HNSCC).METHODS: In 149 FNA samples of 114 patients, SCC-Ag concentration was retrospectively analyzed and associated with diagnosis to establish a cutoff concentration in relation to sensitivity and specificity of HNSCC detection.RESULTS: SCC-Ag was elevated in lymph nodes from patients with HNSCC compared to lymph nodes from other patients (P < 0.01). With 0.3 μg/L as the cutoff concentration, SCC-Ag has 96% sensitivity for detecting HNSCC.CONCLUSIONS: SCC-Ag in FNA is a reliable test for detecting HNSCC in cervical lymph nodes.

KW - FNA

KW - HNSCC

KW - lymph node

KW - SCC-Ag

KW - tumor marker

KW - CANCER

KW - MARKERS

KW - SIZE

U2 - 10.1002/hed.25733

DO - 10.1002/hed.25733

M3 - Article

C2 - 30828886

SN - 1043-3074

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JO - Head and Neck: Journal of the Sciences and Specialties of the Head and Neck

JF - Head and Neck: Journal of the Sciences and Specialties of the Head and Neck

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van Schaik JE , Muller Kobold AC , van der Laan BFAM , van der Vegt B , van Hemel BM , Plaat BEC. Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma. Head and Neck: Journal of the Sciences and Specialties of the Head and Neck. 2019 aug.;41(8):2561-2565. Epub 2019 mrt. 4. doi: 10.1002/hed.25733

Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma

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