Statin Use and Cognitive Function: Population-Based Observational Study with Long-Term Follow-Up

Hanneke Joosten*, Sipke T. Visser, Marlise E. van Eersel, Ron T. Gansevoort, Henk J. G. Bilo, Joris P. Slaets, Gerbrand J. Izaks

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

12 Citaten (Scopus)
334 Downloads (Pure)

Samenvatting

We aimed to evaluate the association between statin use and cognitive function. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0; best score, 175 points) and the Visual Association Test (VAT; low performance, 0-10; high performance, 11-12 points) in an observational study that included 4,095 community-dwelling participants aged 35-82 years. Data on statin use were obtained from a computerized pharmacy database. Analysis were done for the total cohort and subsamples matched on cardiovascular risk (N=1232) or propensity score for statin use (N=3609). We found that a total of 904 participants (10%) used a statin. Statin users were older than non-users: mean age (SD) 61 (10) vs. 52 (11) years (p

Originele taal-2English
Artikelnummere115755
Aantal pagina's15
TijdschriftPLoS ONE
Volume9
Nummer van het tijdschrift12
DOI's
StatusPublished - 26-dec.-2014

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