Statin Use and Cognitive Function: Population-Based Observational Study with Long-Term Follow-Up

Hanneke Joosten*, Sipke T. Visser, Marlise E. van Eersel, Ron T. Gansevoort, Henk J. G. Bilo, Joris P. Slaets, Gerbrand J. Izaks

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

9 Citaten (Scopus)
265 Downloads (Pure)


We aimed to evaluate the association between statin use and cognitive function. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0; best score, 175 points) and the Visual Association Test (VAT; low performance, 0-10; high performance, 11-12 points) in an observational study that included 4,095 community-dwelling participants aged 35-82 years. Data on statin use were obtained from a computerized pharmacy database. Analysis were done for the total cohort and subsamples matched on cardiovascular risk (N=1232) or propensity score for statin use (N=3609). We found that a total of 904 participants (10%) used a statin. Statin users were older than non-users: mean age (SD) 61 (10) vs. 52 (11) years (p

Originele taal-2English
Aantal pagina's15
TijdschriftPLoS ONE
Nummer van het tijdschrift12
StatusPublished - 26-dec-2014

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