Statistical evaluation of PET motion correction methods using MR derived motion fields

Irene Polycarpou*, Charalampos Tsoumpas, Paul K. Marsden

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

6 Citaten (Scopus)


Although there have been various proposed methods for motion correction in PET, there is not sufficient evidence to answer which method is better in terms of image quality and quantification. This study aims to characterize the behavior of the two main motion correction methods in terms of convergence and image properties. During the first method, reconstruct-transform-average (RTA), independent reconstructions of each gate are transformed to a reference gate and averaged. In the second method, motion-compensated image reconstruction (MCIR), all data are used with the motion information within a single reconstruction. The two methods are studied based on the OSEM algorithm. In this investigation motion fields were obtained from real dynamic MR acquisitions and concurrent PET data were simulated from the dynamic MR images. The two motion correction approaches were assessed statistically. Results indicate that MCIR is successful in the recovery of the true values of all regions, whereas RTA has high bias due to the non-negativity constraints and interpolation errors during transformation. It has been demonstrated that whilst at low iterations (i.e. 46 sub-iterations) the two methods have similar noise characteristics; at high iterations MCIR has increased noise. Finally, for low iterations the two methods have marginally similar coefficient of variation (CoV) whereas for large number of iterations RTA has clearly better CoV than MCIR. This study indicates that MCIR may provide superior performance overall to RTA providing the noise can be minimized.

Originele taal-2English
Titel2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011
UitgeverijInstitute of Electrical and Electronics Engineers Inc.
Aantal pagina's7
ISBN van geprinte versie9781467301183
StatusPublished - 2011
Extern gepubliceerdJa
Evenement2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011 - Valencia, Spain
Duur: 23-okt.-201129-okt.-2011

Publicatie series

NaamIEEE Nuclear Science Symposium Conference Record
ISSN van geprinte versie1095-7863


Conference2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011

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