Stochastic modeling of length-dependent telomere shortening in Corvus monedula

J. Grasman*, H. M. Salomons, S. Verhulst

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

12 Citaten (Scopus)

Samenvatting

It was recently shown that, within individuals, longer telomeres shorten at a higher rate. This explorative study deals with a mathematical model of this process. It is a nonlinear differential equation describing length-dependent decrease that can be linked to a Poisson process. The model also takes in account telomere shortening due to the end replication problem. Parameters are fitted using data from samples of red blood cells of free-living juvenile corvids. The Poisson process can be related to oxidative stress causing DNA strand breaks. The shortest telomeres in a genome are the best predictors of survival, and one can therefore hypothesize on functional grounds that short telomeres should be better protected by some control mechanism in the cellular system. However, the present study shows that such a mechanism is not required to explain length-dependent telomere shortening: agents of telomere shortening such as oxidative stress with a certain strength modeled by a Poisson process with an appropriately chosen parameter suffice to generate the observed pattern. (C) 2011 Elsevier Ltd. All rights reserved.

Originele taal-2English
Pagina's (van-tot)1-6
Aantal pagina's6
TijdschriftJournal of Theoretical Biology
Volume282
Nummer van het tijdschrift1
DOI's
StatusPublished - 7-aug-2011

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