Strategies to Target Tumor Immunosuppression

Georgia Koutsoumpli, Oana Draghiciu, Hans W. Nijman, Cesar Oyarce, Toos Daemen

OnderzoeksoutputAcademicpeer review

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The tumor microenvironment is currently in the spotlight of cancer immunology research as a key factor impacting tumor development and progression. While antigen-specific immune responses play a crucial role in tumor rejection, the tumor hampers these immune responses by creating an immunosuppressive microenvironment. Recently, major progress has been achieved in the field of cancer immunotherapy, and several groundbreaking clinical trials demonstrated the potency of such therapeutic interventions in patients. Yet, the responses greatly vary among individuals. This calls for the rational design of more efficacious cancer immunotherapeutic interventions that take into consideration the “immune signature” of the tumor. Multimodality treatment regimens that aim to enhance intratumoral homing and activation of antigen-specific immune effector cells, while simultaneously targeting tumor immunosuppression, are pivotal for potent antitumor immunity.
Originele taal-2English
TitelCancer Immunology
SubtitelBench to Bedside Immunotherapy of Cancers
RedacteurenNima Rezaei
Plaats van productieCham
UitgeverijSpringer International Publishing AG
Aantal pagina's23
ISBN van elektronische versie978-3-030-50287-4
ISBN van geprinte versie978-3-030-50286-7
StatusPublished - 2021

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