Stress and the brain: From adaptation to disease

ER de Kloet*, M Joels, F Holsboer

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

3491 Citaten (Scopus)


In response to stress, the brain activates several neuropeptide-secreting systems. This eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators. By targeting many genes, corticosteroids function in a binary fashion, and serve as a master switch in the control of neuronal and network responses that underlie behavioural adaptation. In genetically predisposed individuals, an imbalance in this binary control mechanism can introduce a bias towards stress-related brain disease after adverse experiences. New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified.

Originele taal-2English
Pagina's (van-tot)463-475
Aantal pagina's13
TijdschriftNature reviews neuroscience
Nummer van het tijdschrift6
StatusPublished - jun.-2005
Extern gepubliceerdJa

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