Stress effects on memory: An update and integration

Lars Schwabe*, Marian Joëls, Benno Roozendaal, Oliver T. Wolf, Melly S. Oitzl

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    470 Citaten (Scopus)


    It is well known that stressful experiences may affect learning and memory processes. Less clear is the exact nature of these stress effects on memory: both enhancing and impairing effects have been reported. These opposite effects may be explained if the different time courses of stress hormone, in particular catecholamine and glucocorticoid, actions are taken into account. Integrating two popular models, we argue here that rapid catecholamine and non-genomic glucocorticoid actions interact in the basolateral amygdala to shift the organism into a 'memory formation mode' that facilitates the consolidation of stressful experiences into long-term memory. The undisturbed consolidation of these experiences is then promoted by genomic glucocorticoid actions that induce a 'memory storage mode', which suppresses competing cognitive processes and thus reduces interference by unrelated material. Highlighting some current trends in the field, we further argue that stress affects learning and memory processes beyond the basolateral amygdala and hippocampus and that stress may pre-program subsequent memory performance when it is experienced during critical periods of brain development. (C) 2011 Elsevier Ltd. All rights reserved.

    Originele taal-2English
    Pagina's (van-tot)1740-1749
    Aantal pagina's10
    TijdschriftNeuroscience and Biobehavioral Reviews
    Nummer van het tijdschrift7
    StatusPublished - aug-2012

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