Structural and functional characterisation of a lytic transglycosylase and two ω-transaminases

Eswarreddy Reddem

Structural and functional characterisation of a lytic transglycosylase and two ω-transaminases

Eswarreddy Reddem

Synthetische Organische Chemie

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This thesis describes the determination and analysis of 3D-structures of enzymes from two different enzyme classes, the lytic transglycosylase MltF from Pseudomonas aeruginosa and two ω-transaminases, an (R)-selective transaminase from an Arthrobacter species and an (S)-selective transaminase from a Pseudomonas species. Lytic transglycosylases may present new targets for the development of broad-spectrum antibiotics, while the transaminases are of biotechnological importance.

Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Dijkstra, Bauke W., Supervisor, Externe Persoon Thunnissen, Andy, Co-supervisor
Datum van toekenning	22-dec.-2015
Plaats van publicatie	[Groningen]
Uitgever	University of Groningen
Gedrukte ISBN's	978-90-367-8503-7
Elektronische ISBN's	978-90-367-8502-0
Status	Published - 2015

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Title and contentsFinal publisher's version, 90,6 KB
Chapter 1Final publisher's version, 13,7 MB
Chapter 2Final publisher's version, 4,59 MB
Chapter 3Final publisher's version, 14,4 MB
Chapter 4Final publisher's version, 15,4 MB
Chapter 5Final publisher's version, 23,6 MB
Chapter 6Final publisher's version, 1,5 MB
Complete thesisFinal publisher's version, 66 MB
PropositionsFinal publisher's version, 49,3 KB

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AU - Reddem, Eswarreddy

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N2 - This thesis describes the determination and analysis of 3D-structures of enzymes from two different enzyme classes, the lytic transglycosylase MltF from Pseudomonas aeruginosa and two ω-transaminases, an (R)-selective transaminase from an Arthrobacter species and an (S)-selective transaminase from a Pseudomonas species. Lytic transglycosylases may present new targets for the development of broad-spectrum antibiotics, while the transaminases are of biotechnological importance.

AB - This thesis describes the determination and analysis of 3D-structures of enzymes from two different enzyme classes, the lytic transglycosylase MltF from Pseudomonas aeruginosa and two ω-transaminases, an (R)-selective transaminase from an Arthrobacter species and an (S)-selective transaminase from a Pseudomonas species. Lytic transglycosylases may present new targets for the development of broad-spectrum antibiotics, while the transaminases are of biotechnological importance.

M3 - Thesis fully internal (DIV)

SN - 978-90-367-8503-7

PB - University of Groningen

CY - [Groningen]

ER -