Structure and regulation of coronavirus genomes: State-of-the-art and novel insights from SARS-CoV-2 studies

Ilaria Manfredonia, Danny Incarnato*

*Bijbehorende auteur voor dit werk

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Coronaviruses (CoV) are positive-sense single-stranded RNA viruses, harboring the largest viral RNA genomes known to date. Apart from the primary sequence encoding for all the viral proteins needed for the generation of new viral particles, certain regions of CoV genomes are known to fold into stable structures, controlling several aspects of CoV life cycle, from the regulation of the discontinuous transcription of subgenomic mRNAs, to the packaging of the genome into new virions. Here we review the current knowledge on CoV RNA structures, discussing it in light of the most recent discoveries made possible by analyses of the SARS-CoV-2 genome.

Originele taal-2English
ArtikelnummerBST20200670
Pagina's (van-tot)341-352
Aantal pagina's12
TijdschriftBiochemical Society Transactions
Volume49
Nummer van het tijdschrift1
Vroegere onlinedatum24-dec-2020
DOI's
StatusPublished - mrt-2021

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