Struktur eines spannungsregulierten Membrantransporters aus Spermien

Martin F. Peter; Valeria Kalienkova; Cristina Paulino

doi:10.1007/s12268-023-2062-0

Struktur eines spannungsregulierten Membrantransporters aus Spermien

Martin F. Peter, Valeria Kalienkova, Cristina Paulino^*

^*Corresponding author voor dit werk

Onderzoeksoutput: Article › Academic › peer review

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The sperm-specific Na⁺/H⁺ exchanger SLC9C1 stands out by its unique tripartite domain composition. It is the first known secondary-active transporter which is directly activated by membrane voltage via a voltage-sensing domain (VSD). Our cryo-EM structures of sea urchin SLC9C1 reveal the domain arrangement and new structural coupling elements, allowing us to propose a mechanism for a voltage-activated alternative access mechanism.

Originele taal-2	German
Pagina's (van-tot)	721-724
Aantal pagina's	4
Tijdschrift	BIOspektrum
Volume	29
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.1007/s12268-023-2062-0
Status	Published - nov.-2023

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10.1007/s12268-023-2062-0Licentie: CC BY

Struktur eines spannungsregulierten Membrantransporters aus SpermienFinal publisher's version, 488 KBLicentie: CC BY

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