Studies on the application of the Passerini reaction and enzymatic procedures to the synthesis of tripeptide mimetics

Wiktor Szymanski, Magdalena Zwolinska, Ryszard Ostaszewski*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

30 Citaten (Scopus)


A new, efficient method for the multicomponent synthesis of tripeptide mimetics is presented. Simple, chemoenzymatic transformations of Passerini reaction products enable the introduction of varied amino acid moieties into the tripeptide scaffold, with control of the stereochemistry. Additionally, this method allows the convenient introduction of a methyl group to the amide nitrogen, leading to derivatives of N-methylated amino acids-compounds of interest for medicinal chemistry. (C) 2007 Elsevier Ltd. All rights reserved.

Originele taal-2English
Pagina's (van-tot)7647-7653
Aantal pagina's7
Nummer van het tijdschrift32
StatusPublished - 6-aug-2007
Extern gepubliceerdJa

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