@book{4a8fe65d30694062b4e3f58ec43469f4,
title = "Studying Hepatic Stellate Cell Senescence",
abstract = "Hepatic stellate cells (HSCs) are the key effector cells in liver fibrosis. They are the main producers of excessive amounts of extracellular matrix components during fibrogenesis and therefore a potential target for the treatment of liver fibrosis. Induction of senescence in HSCs may be a promising strategy to slow down, stop, or even reverse fibrogenesis. Senescence is a complex and heterogeneous process linked to fibrosis and cancer, but the exact mechanism and relevant markers can be cell-type dependent. Therefore, many markers of senescence have been proposed, and many methods to detect senescence have been developed. In this chapter, we review relevant methods and biomarkers to detect cellular senescence in hepatic stellate cells.",
keywords = "Humans, Hepatic Stellate Cells, Kupffer Cells, Cellular Senescence, Liver Cirrhosis, Research, Liver",
author = "Serna-Salas, {Sandra A} and Abel Soto-Gamez and Zongmei Wu and Myrthe Klaver and Han Moshage",
note = "{\textcopyright} 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2023",
month = may,
day = "30",
doi = "10.1007/978-1-0716-3207-9_6",
language = "English",
isbn = "978-1-0716-3206-2",
volume = "2669",
series = "Methods in molecular biology (Clifton, N.J.)",
publisher = "Springer",
}