Substrate exploitation of multicomponent reactions toward diverse scaffolds and applications in medicinal chemistry

MCR chemistry is an emerging and promising tool for organic synthesis and medicinal chemistry. In this thesis, we enriched the probable scaffolds of MCR by exploring its isocyanide, aldehyde and acid substrates. Besides, post-cyclization of MCR products was performed as well, and generated an efficient methodology towards drug-like compounds. The discovery of IL-17A antagonists through MCRs was accomplished in the last chapter, indicating the broad applicability of MCRs in the drug development process.