TY - JOUR
T1 - Subtherapeutic Exposure of Ganciclovir in Children Despite Appropriate Dosing
T2 - A Short Communication
AU - Marfil, Sjanene
AU - Märtson, Anne-Grete
AU - Toren-Wielema, Marlous
AU - Leer-Buter, Coretta van
AU - Schölvinck, Elisabeth H
AU - Alffenaar, Jan-Willem C
AU - Touw, Daan J
AU - Sturkenboom, Marieke G G
N1 - Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.
PY - 2023/4
Y1 - 2023/4
N2 - Therapeutic drug monitoring (TDM) results for ganciclovir in 12 different treatment episodes showed large intraindividual and interindividual variabilities in the trough concentration and area under the 24-hour concentration-time curve (AUC24). Despite adequate valganciclovir dosing, subtherapeutic concentrations were found in 30% of the treatment episodes. A decrease in viral load was observed regardless of subtherapeutic exposure. These findings show the need for target concentration evaluation and assessment of the applicability of ganciclovir TDM in children.
AB - Therapeutic drug monitoring (TDM) results for ganciclovir in 12 different treatment episodes showed large intraindividual and interindividual variabilities in the trough concentration and area under the 24-hour concentration-time curve (AUC24). Despite adequate valganciclovir dosing, subtherapeutic concentrations were found in 30% of the treatment episodes. A decrease in viral load was observed regardless of subtherapeutic exposure. These findings show the need for target concentration evaluation and assessment of the applicability of ganciclovir TDM in children.
KW - Child
KW - Humans
KW - Ganciclovir/therapeutic use
KW - Antiviral Agents/therapeutic use
KW - Cytomegalovirus Infections/drug therapy
KW - Valganciclovir/therapeutic use
KW - Drug Monitoring
U2 - 10.1097/FTD.0000000000001050
DO - 10.1097/FTD.0000000000001050
M3 - Article
C2 - 36920505
SN - 0163-4356
VL - 45
SP - 269
EP - 272
JO - Therapeutic Drug Monitoring
JF - Therapeutic Drug Monitoring
IS - 2
ER -