TY - JOUR
T1 - Suicidality Treatment Occurring in Paediatrics (STOP) Medication Suicidality Side Effects Scale in young people in two cohorts across Europe
AU - Santosh, Paramala
AU - Sala, Regina
AU - Lievesley, Kate
AU - Singh, Jatinder
AU - Arango, Celso
AU - Buitelaar, Jan K.
AU - Castro-Fornieles, Josefina
AU - Coghill, David
AU - Dittmann, Ralf W.
AU - Flamarique, Itziar
AU - Hoekstra, Pieter J.
AU - Llorente, Cloe
AU - Purper-Ouakil, Diane
AU - Schulze, Ulrike
AU - Zuddas, Alessandro
AU - Parnell, Nathan
AU - Mohan, Mohapradeep
AU - Fiori, Federico
N1 - Publisher Copyright:
© 2023 BMJ Publishing Group. All rights reserved.
PY - 2023/12/13
Y1 - 2023/12/13
N2 - Objectives As part of the € Suicidality: Treatment Occurring in Paediatrics (STOP)' study, we developed and performed psychometric validation of an electronic-clinical-outcome-assessment (eCOA), which included a patient-reported-outcome (ePRO), an observer-rated-outcome (eObsRO) for parents/carers and a clinician-reported-outcome (eClinRO) that allows identification and monitoring of medication-related suicidality (MRS) in adolescents. Design STOP: Prospective study: A two phase validation study to assess the impact of medication on suicidal ideations. Setting Six participating countries: Netherlands, UK, Germany, France, Spain and Italy that were part of the Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 261411. Participants Cohort 1 consisted of 41 adolescent-completions, 50 parent-completions and 56 clinician-completions. Cohort 2 consisted of 244 adolescent-completions, 198 parent-completions and 240 clinician-completions from across the six countries. The scale was administered only to participants who have screened positive for the STOP-Suicidality Assessment Scale (STOP-SAS). Results A total of 24 items for the development of the STOP-Medication Suicidality Side Effects Scale (STOP-MS 3) were identified and three versions (for patients, parents and clinicians) of the STOP-MS 3 were developed and validated in two separate study cohorts comprising of adolescents, their parents and clinicians. Cronbach's α coefficients were above 0.85 for all domains. The inter-rater reliability of the STOP-MS 3 was good and significant for the adolescent (ePRO), clinician (eClinRO) (r=0.613), parent (eObsRO) versions of the scale (r=0.394) and parent and clinician (r=0.347). Exploratory factor analysis identified a 3-factor model across 24 items for the adolescent and parent version of the scale: (1) Emotional Dysregulation, (2) Somatic Dysregulation and (3) Behavioural Dysregulation. For the clinician version, a 4-factor model defined the scale structure: (1) Somatic Dysregulation, (2) Emotional Dysregulation, (3) Behavioural Dysregulation and (4) Mood Dysregulation. Conclusion These findings suggest that the STOP-MS 3 scale, a web-based eCOA, allows identification and monitoring of MRS in the adolescent population and shows good reliability and validity.
AB - Objectives As part of the € Suicidality: Treatment Occurring in Paediatrics (STOP)' study, we developed and performed psychometric validation of an electronic-clinical-outcome-assessment (eCOA), which included a patient-reported-outcome (ePRO), an observer-rated-outcome (eObsRO) for parents/carers and a clinician-reported-outcome (eClinRO) that allows identification and monitoring of medication-related suicidality (MRS) in adolescents. Design STOP: Prospective study: A two phase validation study to assess the impact of medication on suicidal ideations. Setting Six participating countries: Netherlands, UK, Germany, France, Spain and Italy that were part of the Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 261411. Participants Cohort 1 consisted of 41 adolescent-completions, 50 parent-completions and 56 clinician-completions. Cohort 2 consisted of 244 adolescent-completions, 198 parent-completions and 240 clinician-completions from across the six countries. The scale was administered only to participants who have screened positive for the STOP-Suicidality Assessment Scale (STOP-SAS). Results A total of 24 items for the development of the STOP-Medication Suicidality Side Effects Scale (STOP-MS 3) were identified and three versions (for patients, parents and clinicians) of the STOP-MS 3 were developed and validated in two separate study cohorts comprising of adolescents, their parents and clinicians. Cronbach's α coefficients were above 0.85 for all domains. The inter-rater reliability of the STOP-MS 3 was good and significant for the adolescent (ePRO), clinician (eClinRO) (r=0.613), parent (eObsRO) versions of the scale (r=0.394) and parent and clinician (r=0.347). Exploratory factor analysis identified a 3-factor model across 24 items for the adolescent and parent version of the scale: (1) Emotional Dysregulation, (2) Somatic Dysregulation and (3) Behavioural Dysregulation. For the clinician version, a 4-factor model defined the scale structure: (1) Somatic Dysregulation, (2) Emotional Dysregulation, (3) Behavioural Dysregulation and (4) Mood Dysregulation. Conclusion These findings suggest that the STOP-MS 3 scale, a web-based eCOA, allows identification and monitoring of MRS in the adolescent population and shows good reliability and validity.
KW - child & adolescent psychiatry
KW - developmental neurology & neurodisability
KW - information technology
KW - mental health
KW - suicide & self-harm
UR - http://www.scopus.com/inward/record.url?scp=85179771555&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2022-068140
DO - 10.1136/bmjopen-2022-068140
M3 - Article
C2 - 38097236
AN - SCOPUS:85179771555
SN - 2044-6055
VL - 13
JO - BMJ Open
JF - BMJ Open
IS - 12
M1 - e068140
ER -