Susceptibility Testing of Antibiotics That Degrade Faster than the Doubling Time of Slow-Growing Mycobacteria: Ertapenem Sterilizing Effect versus Mycobacterium tuberculosis

Shashikant Srivastava, Sander P. van Rijn, A. Mireille A. Wessels, Jan-Willem C. Alffenaar*, Tawanda Gumbo

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

18 Citaten (Scopus)

Samenvatting

Drug susceptibility tests (DSTs) for Mycobacterium tuberculosis require at least 7 days of incubation. Drugs that are unstable at 37 degrees C, such as ertapenem, are likely to be degraded before killing or inhibiting slow-growing bacteria. This would alter the MICs of these drugs, including ertapenem, leading to falsely high MICs. Here, we describe a new strategy we developed to perform DSTs and measure MICs for such unstable compounds.

Originele taal-2English
Pagina's (van-tot)3193-3195
Aantal pagina's3
TijdschriftAntimicrobial Agents and Chemotherapy
Volume60
Nummer van het tijdschrift5
DOI's
StatusPublished - mei-2016

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