Sustainable multicomponent indole synthesis with broad scope

Xiaofang Lei, Giasemi K. Angeli, Constantinos G. Neochoritis, Alexander Dömling*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

1 Citaat (Scopus)
3 Downloads (Pure)


The most preferred heterocyclic indole core was de novo assembled by an innovative 2-step reaction from inexpensive and broadly available anilines, glyoxal dimethyl acetal, formic acid and isocyanides involving an Ugi multicomponent reaction followed by an acid induced cyclization. As opposed to many other indoles syntheses, our method delivers under mild and benign conditions using ethanol as solvent and no metal catalyst. The scope of the reactions was scouted and 20 derivatives are described.

Originele taal-2English
Pagina's (van-tot) 6168–6171
Aantal pagina's4
TijdschriftGreen Chemistry
Nummer van het tijdschrift16
StatusPublished - 21-jul.-2022

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