Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues

Matthijs van der Knaap; Eefje Engels; Henk J. Busscher; Jose M. Otero; Antonio L. Llamas-Saiz; Mark J. van Raaij; Roos H. Mars-Groenendijk; Daan Noort; Gijsbert A. van der Marel; Herman S. Overkleeft; Mark Overhand

doi:10.1016/j.bmc.2009.07.042

Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues

Matthijs van der Knaap, Eefje Engels, Henk J. Busscher, Jose M. Otero, Antonio L. Llamas-Saiz, Mark J. van Raaij, Roos H. Mars-Groenendijk, Daan Noort, Gijsbert A. van der Marel, Herman S. Overkleeft, Mark Overhand^*

^*Corresponding author voor dit werk

Man, Biomaterials and Microbes (MBM)

Onderzoeksoutput › Academic › peer review

13 Citaten (Scopus)

Samenvatting

The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified D-phenylalanine residue, their antibacterial properties against several Gram positive and negative strains, as well as their hemolytic activity is reported. (C) 2009 Elsevier Ltd. All rights reserved.

Originele taal-2	English
Pagina's (van-tot)	6318-6328
Aantal pagina's	11
Tijdschrift	Bioorganic & Medicinal Chemistry
Volume	17
Nummer van het tijdschrift	17
DOI's	https://doi.org/10.1016/j.bmc.2009.07.042
Status	Published - 1-sep.-2009

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CCDC 737680: Experimental Crystal Structure Determination
van der Knaap, M. (Contributor), Engels, E. (Contributor), Busscher, H. J. (Contributor), Otero, J. M. (Contributor), Llamas-Saiz, A. L. (Contributor), van Raaij, M. J. (Contributor), Mars-Groenendijk, R. H. (Contributor), Noort, D. (Contributor), van der Marel, G. A. (Contributor), Overkleeft, H. S. (Contributor) & Overhand, M. (Contributor), University of Groningen, 14-apr.-2010
DOI: 10.5517/ccsrm48
Dataset
CCDC 737679: Experimental Crystal Structure Determination
van der Knaap, M. (Contributor), Engels, E. (Contributor), Busscher, H. J. (Contributor), Otero, J. M. (Contributor), Llamas-Saiz, A. L. (Contributor), van Raaij, M. J. (Contributor), Mars-Groenendijk, R. H. (Contributor), Noort, D. (Contributor), van der Marel, G. A. (Contributor), Overkleeft, H. S. (Contributor) & Overhand, M. (Contributor), University of Groningen, 14-apr.-2010
DOI: 10.5517/ccsrm37
Dataset

Citeer dit

van der Knaap, M., Engels, E., Busscher, H. J., Otero, J. M., Llamas-Saiz, A. L., van Raaij, M. J., Mars-Groenendijk, R. H., Noort, D., van der Marel, G. A., Overkleeft, H. S., & Overhand, M. (2009). Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues. Bioorganic & Medicinal Chemistry, 17(17), 6318-6328. https://doi.org/10.1016/j.bmc.2009.07.042

@article{b0fc2f1eca524dba99921a6971c3b360,

title = "Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues",

abstract = "The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified D-phenylalanine residue, their antibacterial properties against several Gram positive and negative strains, as well as their hemolytic activity is reported. (C) 2009 Elsevier Ltd. All rights reserved.",

keywords = "Anti-microbial peptides, Gramicidin S derivatives, Biological profile, AMINO-ACIDS, ANTIMICROBIAL PEPTIDES, DIFFRACTION DATA, SOLID-PHASE, CONFORMATION, MODEL",

author = "{van der Knaap}, Matthijs and Eefje Engels and Busscher, {Henk J.} and Otero, {Jose M.} and Llamas-Saiz, {Antonio L.} and {van Raaij}, {Mark J.} and Mars-Groenendijk, {Roos H.} and Daan Noort and {van der Marel}, {Gijsbert A.} and Overkleeft, {Herman S.} and Mark Overhand",

year = "2009",

month = sep,

day = "1",

doi = "10.1016/j.bmc.2009.07.042",

language = "English",

volume = "17",

pages = "6318--6328",

journal = "Bioorganic & Medicinal Chemistry",

issn = "0968-0896",

publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

number = "17",

}

van der Knaap, M, Engels, E, Busscher, HJ, Otero, JM, Llamas-Saiz, AL, van Raaij, MJ, Mars-Groenendijk, RH, Noort, D, van der Marel, GA, Overkleeft, HS & Overhand, M 2009, 'Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues', Bioorganic & Medicinal Chemistry, vol. 17, nr. 17, blz. 6318-6328. https://doi.org/10.1016/j.bmc.2009.07.042

TY - JOUR

T1 - Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues

AU - van der Knaap, Matthijs

AU - Engels, Eefje

AU - Busscher, Henk J.

AU - Otero, Jose M.

AU - Llamas-Saiz, Antonio L.

AU - van Raaij, Mark J.

AU - Mars-Groenendijk, Roos H.

AU - Noort, Daan

AU - van der Marel, Gijsbert A.

AU - Overkleeft, Herman S.

AU - Overhand, Mark

PY - 2009/9/1

Y1 - 2009/9/1

N2 - The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified D-phenylalanine residue, their antibacterial properties against several Gram positive and negative strains, as well as their hemolytic activity is reported. (C) 2009 Elsevier Ltd. All rights reserved.

AB - The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified D-phenylalanine residue, their antibacterial properties against several Gram positive and negative strains, as well as their hemolytic activity is reported. (C) 2009 Elsevier Ltd. All rights reserved.

KW - Anti-microbial peptides

KW - Gramicidin S derivatives

KW - Biological profile

KW - AMINO-ACIDS

KW - ANTIMICROBIAL PEPTIDES

KW - DIFFRACTION DATA

KW - SOLID-PHASE

KW - CONFORMATION

KW - MODEL

U2 - 10.1016/j.bmc.2009.07.042

DO - 10.1016/j.bmc.2009.07.042

M3 - Article

SN - 0968-0896

VL - 17

SP - 6318

EP - 6328

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

IS - 17

ER -

Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues

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Datasets

CCDC 737680: Experimental Crystal Structure Determination

CCDC 737679: Experimental Crystal Structure Determination

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