Samenvatting
The synthesis of functionalized (benz)aldehydes, via a two-step, one-pot procedure, is presented. The method employs a stable aluminum hemiaminal as a tetrahedral intermediate, protecting a latent aldehyde, making it suitable for subsequent cross-coupling with (strong nucleophilic) organometallic reagents, leading to a variety of alkyl and aryl substituted benzaldehydes. This very fast methodology also facilitates the effective synthesis of a 11C radiolabeled aldehyde. Aluminum-ate complexes enable transmetalation of alkyl fragments onto palladium and subsequent cross-coupling.
Originele taal-2 | English |
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Pagina's (van-tot) | 4087-4091 |
Aantal pagina's | 5 |
Tijdschrift | Organic letters |
Volume | 21 |
Nummer van het tijdschrift | 11 |
DOI's | |
Status | Published - 7-jun.-2019 |