System-wide molecular evidence for phenotypic buffering in Arabidopsis

Jingyuan Fu; Joost J. B. Keurentjes; Harro Bouwmeester; Twan America; Francel W. A. Verstappen; Jane L. Ward; Michael H. Beale; Ric C. H. de Vos; Martijn Dijkstra; Richard A. Scheltema; Frank Johannes; Maarten Koornneef; Dick Vreugdenhil; Rainer Breitling; Ritsert C. Jansen

doi:10.1038/ng.308

System-wide molecular evidence for phenotypic buffering in Arabidopsis

Jingyuan Fu, Joost J. B. Keurentjes, Harro Bouwmeester, Twan America, Francel W. A. Verstappen, Jane L. Ward, Michael H. Beale, Ric C. H. de Vos, Martijn Dijkstra, Richard A. Scheltema, Frank Johannes, Maarten Koornneef, Dick Vreugdenhil, Rainer Breitling, Ritsert C. Jansen^*

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

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We profiled 162 lines of Arabidopsis for variation in transcript, protein and metabolite abundance using mRNA microarrays, two-dimensional polyacrylamide gel electrophoresis, gas chromatography time-of-flight mass spectrometry, liquid chromatography quadrupole time-of-flight mass spectrometry, and proton nuclear magnetic resonance. We added all publicly available phenotypic data from the same lines and mapped quantitative trait loci (QTL) for 40,580 molecular and 139 phenotypic traits. We found six QTL hot spots with major, system-wide effects, suggesting there are six breakpoints in a system otherwise buffered against many of the 500,000 SNPs.

Originele taal-2	English
Pagina's (van-tot)	166-167
Aantal pagina's	2
Tijdschrift	Nature Genetics
Volume	41
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1038/ng.308
Status	Published - feb.-2009

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Fu, J., Keurentjes, J. J. B., Bouwmeester, H., America, T., Verstappen, F. W. A., Ward, J. L., Beale, M. H., de Vos, R. C. H., Dijkstra, M., Scheltema, R. A., Johannes, F., Koornneef, M., Vreugdenhil, D., Breitling, R., & Jansen, R. C. (2009). System-wide molecular evidence for phenotypic buffering in Arabidopsis. Nature Genetics, 41(2), 166-167. https://doi.org/10.1038/ng.308

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abstract = "We profiled 162 lines of Arabidopsis for variation in transcript, protein and metabolite abundance using mRNA microarrays, two-dimensional polyacrylamide gel electrophoresis, gas chromatography time-of-flight mass spectrometry, liquid chromatography quadrupole time-of-flight mass spectrometry, and proton nuclear magnetic resonance. We added all publicly available phenotypic data from the same lines and mapped quantitative trait loci (QTL) for 40,580 molecular and 139 phenotypic traits. We found six QTL hot spots with major, system-wide effects, suggesting there are six breakpoints in a system otherwise buffered against many of the 500,000 SNPs.",

keywords = "BIOLOGICAL ROBUSTNESS, GENETIC GENOMICS, NETWORKS, EXPRESSION, DISEASE",

author = "Jingyuan Fu and Keurentjes, {Joost J. B.} and Harro Bouwmeester and Twan America and Verstappen, {Francel W. A.} and Ward, {Jane L.} and Beale, {Michael H.} and {de Vos}, {Ric C. H.} and Martijn Dijkstra and Scheltema, {Richard A.} and Frank Johannes and Maarten Koornneef and Dick Vreugdenhil and Rainer Breitling and Jansen, {Ritsert C.}",

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doi = "10.1038/ng.308",

language = "English",

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T1 - System-wide molecular evidence for phenotypic buffering in Arabidopsis

AU - Fu, Jingyuan

AU - Keurentjes, Joost J. B.

AU - Bouwmeester, Harro

AU - America, Twan

AU - Verstappen, Francel W. A.

AU - Ward, Jane L.

AU - Beale, Michael H.

AU - de Vos, Ric C. H.

AU - Dijkstra, Martijn

AU - Scheltema, Richard A.

AU - Johannes, Frank

AU - Koornneef, Maarten

AU - Vreugdenhil, Dick

AU - Breitling, Rainer

AU - Jansen, Ritsert C.

PY - 2009/2

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N2 - We profiled 162 lines of Arabidopsis for variation in transcript, protein and metabolite abundance using mRNA microarrays, two-dimensional polyacrylamide gel electrophoresis, gas chromatography time-of-flight mass spectrometry, liquid chromatography quadrupole time-of-flight mass spectrometry, and proton nuclear magnetic resonance. We added all publicly available phenotypic data from the same lines and mapped quantitative trait loci (QTL) for 40,580 molecular and 139 phenotypic traits. We found six QTL hot spots with major, system-wide effects, suggesting there are six breakpoints in a system otherwise buffered against many of the 500,000 SNPs.

AB - We profiled 162 lines of Arabidopsis for variation in transcript, protein and metabolite abundance using mRNA microarrays, two-dimensional polyacrylamide gel electrophoresis, gas chromatography time-of-flight mass spectrometry, liquid chromatography quadrupole time-of-flight mass spectrometry, and proton nuclear magnetic resonance. We added all publicly available phenotypic data from the same lines and mapped quantitative trait loci (QTL) for 40,580 molecular and 139 phenotypic traits. We found six QTL hot spots with major, system-wide effects, suggesting there are six breakpoints in a system otherwise buffered against many of the 500,000 SNPs.

KW - BIOLOGICAL ROBUSTNESS

KW - GENETIC GENOMICS

KW - NETWORKS

KW - EXPRESSION

KW - DISEASE

U2 - 10.1038/ng.308

DO - 10.1038/ng.308

M3 - Article

SN - 1061-4036

VL - 41

SP - 166

EP - 167

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -

System-wide molecular evidence for phenotypic buffering in Arabidopsis

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