T-cell Cholesterol Accumulation, Aging, and Atherosclerosis

Venetia Bazioti, Benedek Halmos, Marit Westerterp*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

3 Citaten (Scopus)
41 Downloads (Pure)


PURPOSE OF REVIEW: The majority of leukocytes in advanced human atherosclerotic plaques are T-cells. T-cell subsets exert pro- or anti-atherogenic effects largely via the cytokines they secrete. T regulatory cells (T regs) are anti-inflammatory, but may lose these properties during atherosclerosis, proposed to be downstream of cholesterol accumulation. Aged T-cells also accumulate cholesterol. The effects of T-cell cholesterol accumulation on T-cell fate and atherosclerosis are not uniform.

RECENT FINDINGS: T-cell cholesterol accumulation enhances differentiation into pro-atherogenic cytotoxic T-cells and boosts their killing capacity, depending on the localization and extent of cholesterol accumulation. Excessive cholesterol accumulation induces T-cell exhaustion or T-cell apoptosis, the latter decreasing atherosclerosis but impairing T-cell functionality in terms of killing capacity and proliferation. This may explain the compromised T-cell functionality in aged T-cells and T-cells from CVD patients. The extent of T-cell cholesterol accumulation and its cellular localization determine T-cell fate and downstream effects on atherosclerosis and T-cell functionality.

Originele taal-2English
Pagina's (van-tot)527-534
Aantal pagina's8
TijdschriftCurrent atherosclerosis reports
Nummer van het tijdschrift9
StatusPublished - sep.-2023


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