Targeted drug delivery to the tumor neovasculature

Grietje Molema*

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    5 Citaten (Scopus)

    Samenvatting

    The angiogenic process that accompanies solid tumor growth provides an excellent opportunity for the development of targeted drug delivery to selectively block the blood supply of a tumor. Several tumor endothelial associated molecules, preferentially expressed during the angiogenic phase, have been put forward as target epitopes for this purpose, and numerous strategies have now been investigated for therapeutic potential. This chapter provides a concise, though not complete, overview on delivery devices, target epitopes and targeting ligands, and pharmacological effector moieties studied for this purpose. As the final aim is to develop targeted drug delivery systems for the patient, the last part of the chapter focuses on issues that (still) need to be addressed to make successful clinical application a realistic aim.

    Originele taal-2English
    TitelAngiogenesis
    SubtitelAn Integrative Approach From Science to Medicine
    RedacteurenWilliam D. Figg, Judah Folkman
    UitgeverijSpringer
    Pagina's283-297
    Aantal pagina's15
    ISBN van geprinte versie9780387715179
    DOI's
    StatusPublished - 2008

    Citeer dit