Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags

Jiaying Han, Jing Sun, Shanshan Song, Leonie Beljaars, Geny M M Groothuis, Hjalmar Permentier, Rainer Bischoff, Gyorgy B Halmos, Cornelia J Verhoeven, Erika R Amstalden van Hove, Peter Horvatovich*, Angela Casini

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

7 Citaten (Scopus)
2 Downloads (Pure)

Samenvatting

Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(ii) polypyridine complexes as mass-tags for imaging of integrins avß3 in human cancer tissues.

Originele taal-2English
Pagina's (van-tot)5941-5944
Aantal pagina's4
TijdschriftChemical communications (Cambridge, England)
Volume56
Nummer van het tijdschrift44
Vroegere onlinedatum29-apr-2020
DOI's
StatusPublished - 4-jun-2020

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