Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags

Jiaying Han; Jing Sun; Shanshan Song; Leonie Beljaars; Geny M M Groothuis; Hjalmar Permentier; Rainer Bischoff; Gyorgy B Halmos; Cornelia J Verhoeven; Erika R Amstalden van Hove; Peter Horvatovich; Angela Casini

doi:10.1039/d0cc00774a

Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags

Jiaying Han, Jing Sun, Shanshan Song, Leonie Beljaars, Geny M M Groothuis, Hjalmar Permentier, Rainer Bischoff, Gyorgy B Halmos, Cornelia J Verhoeven, Erika R Amstalden van Hove, Peter Horvatovich^*, Angela Casini

^*Bijbehorende auteur voor dit werk

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Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(ii) polypyridine complexes as mass-tags for imaging of integrins avß3 in human cancer tissues.

Originele taal-2	English
Pagina's (van-tot)	5941-5944
Aantal pagina's	4
Tijdschrift	Chemical communications (Cambridge, England)
Volume	56
Nummer van het tijdschrift	44
Vroegere onlinedatum	29-apr.-2020
DOI's	https://doi.org/10.1039/d0cc00774a
Status	Published - 4-jun.-2020

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10.1039/d0cc00774a

Targeted imaging of integrins in cancer tissuesusing photocleavable Ru(II) polypyridinecomplexes as mass-tagsFinal publisher's version, 1,98 MBLicentie: Taverne

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Han, J., Sun, J., Song, S., Beljaars, L., Groothuis, G. M. M., Permentier, H., Bischoff, R., Halmos, G. B., Verhoeven, C. J., Amstalden van Hove, E. R., Horvatovich, P., & Casini, A. (2020). Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags. Chemical communications (Cambridge, England), 56(44), 5941-5944. https://doi.org/10.1039/d0cc00774a

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title = "Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags",

abstract = "Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(ii) polypyridine complexes as mass-tags for imaging of integrins av{\ss}3 in human cancer tissues.",

keywords = "HIGH-SPATIAL-RESOLUTION, TRANSMISSION GEOMETRY, SPECTROMETRY, RUTHENIUM, ALPHA-V-BETA-3, DESORPTION",

author = "Jiaying Han and Jing Sun and Shanshan Song and Leonie Beljaars and Groothuis, {Geny M M} and Hjalmar Permentier and Rainer Bischoff and Halmos, {Gyorgy B} and Verhoeven, {Cornelia J} and {Amstalden van Hove}, {Erika R} and Peter Horvatovich and Angela Casini",

year = "2020",

month = jun,

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doi = "10.1039/d0cc00774a",

language = "English",

volume = "56",

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Han, J, Sun, J, Song, S , Beljaars, L , Groothuis, GMM , Permentier, H , Bischoff, R , Halmos, GB , Verhoeven, CJ, Amstalden van Hove, ER, Horvatovich, P & Casini, A 2020, 'Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags', Chemical communications (Cambridge, England), vol. 56, nr. 44, blz. 5941-5944. https://doi.org/10.1039/d0cc00774a

TY - JOUR

T1 - Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags

AU - Han, Jiaying

AU - Sun, Jing

AU - Song, Shanshan

AU - Beljaars, Leonie

AU - Groothuis, Geny M M

AU - Permentier, Hjalmar

AU - Bischoff, Rainer

AU - Halmos, Gyorgy B

AU - Verhoeven, Cornelia J

AU - Amstalden van Hove, Erika R

AU - Horvatovich, Peter

AU - Casini, Angela

PY - 2020/6/4

Y1 - 2020/6/4

N2 - Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(ii) polypyridine complexes as mass-tags for imaging of integrins avß3 in human cancer tissues.

AB - Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(ii) polypyridine complexes as mass-tags for imaging of integrins avß3 in human cancer tissues.

KW - HIGH-SPATIAL-RESOLUTION

KW - TRANSMISSION GEOMETRY

KW - SPECTROMETRY

KW - RUTHENIUM

KW - ALPHA-V-BETA-3

KW - DESORPTION

U2 - 10.1039/d0cc00774a

DO - 10.1039/d0cc00774a

M3 - Article

C2 - 32347235

SN - 1359-7345

VL - 56

SP - 5941

EP - 5944

JO - Chemical Communications (Cambridge, United Kingdom)

JF - Chemical Communications (Cambridge, United Kingdom)

IS - 44

ER -