Targeted therapy, molecular imaging and biomarkers in cancer treatment: Getting more personalized

Martha Willemine den Hollander


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    In recent years, great progress has been made in the development of targeted therapy against cancer. However, it is also more recognized that these treatments are often only successful in a subgroup of patients. One of the current challenges in oncology lies in identifying these patients and thereby avoiding treating patients with non-effective treatments and thus avoid side-effects of these drugs and reduce costs. This way, cancer medicine will become more and more personalized: a specific therapy for a specific tumor in a specific patient, with as little side-effects as possible. In this thesis, different ways of selecting patients are studied. Using PET scans with different radioactive labeled markers might be useful to predict whether a patient will benefit from a certain treatment. Furthermore, we studied whether biomarkers measured in blood samples can be used to predict side-effects in patients.
    Originele taal-2English
    KwalificatieDoctor of Philosophy
    Toekennende instantie
    • Rijksuniversiteit Groningen
    • Gietema, Jourik, Supervisor
    • de Vries, Liesbeth, Supervisor
    • Walenkamp, Annemiek, Co-supervisor
    • van den Bent, Martin J., Beoordelingscommissie, Externe Persoon
    • Kosterink, Jos, Beoordelingscommissie
    • van Vugt, Marcel, Beoordelingscommissie
    Datum van toekenning14-okt-2015
    Plaats van publicatie[Groningen]
    Gedrukte ISBN's9789462598058
    Elektronische ISBN's9789462598201
    StatusPublished - 2015

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