Targeting HDAC Complexes in Asthma and COPD

Martijn R. H. Zwinderman, Sander de Weerd, Frank J. Dekker*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

17 Citaten (Scopus)
163 Downloads (Pure)

Samenvatting

Around three million patients die due to airway inflammatory diseases each year. The most notable of these diseases are asthma and chronic obstructive pulmonary disease (COPD). Therefore, new therapies are urgently needed. Promising targets are histone deacetylases (HDACs), since they regulate posttranslational protein acetylation. Over a thousand proteins are reversibly acetylated, and acetylation critically influences aberrant intracellular signaling pathways in asthma and COPD. The diverse set of selective and non-selective HDAC inhibitors used in pre-clinical models of airway inflammation show promising results, but several challenges still need to be overcome. One such challenge is the design of HDAC inhibitors with unique selectivity profiles, such as selectivity towards specific HDAC complexes. Novel strategies to disrupt HDAC complexes should be developed to validate HDACs further as targets for new anti-inflammatory pulmonary treatments.

Originele taal-2English
Artikelnummer19
Aantal pagina's25
TijdschriftEpigenomes
Volume3
Nummer van het tijdschrift3
DOI's
StatusPublished - 7-sep.-2019

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