Targeting liposomes to endothelial cells in inflammatory diseases

    OnderzoeksoutputAcademicpeer review

    7 Citaten (Scopus)

    Samenvatting

    The endothelium covers the vascular wall of all blood vessels in the body and comprises 1013 endothelial cells (ECs) in an adult (1). Their excellent accessibility for drugs present in the systemic circulation and their involvement in a large variety of physiological and pathophysiological processes make ECs ideal targets for targeted liposome-mediated drug delivery. The heterogeneity of the endothelium with respect to appearance and function allows for drug delivery approaches that are either organ and/or disease specific. Despite these features, research on liposome-mediated drug delivery to ECs is limited. This is undoubtedly related to the fact that ECs are generally refractory to liposome uptake (2) and that the use of specific targeting devices are a prerequisite for liposome uptake by selected cell subsets.

    Originele taal-2English
    TitelLiposome Technology
    SubtitelInteractions of Liposomes with the Biological Milieu
    UitgeverijCRC Press
    Pagina's127-150
    Aantal pagina's24
    ISBN van elektronische versie9780849397288
    ISBN van geprinte versie9780849397257
    StatusPublished - 1-jan.-2006

    Citeer dit