TB-HIV co-infection in the Netherlands: estimating prevalence and under-reporting in national registration databases using a capture-recapture analysis

Frank van Leth*, Kirsten Evenblij, Ferdinand Wit, Albert Kiers, Herman Sprenger, Maurits Verhagen, Mariska Hillebregt, Nico Kalisvaart, Henrieke Schimmel, Annelies Verbon

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    9 Citaten (Scopus)


    Background Knowledge of the HIV status in patients with tuberculosis (TB) and vice versa is crucial for proper individual patient management, while knowledge of the prevalence of co-infection guides preventive and therapeutic strategies. The aim of the study was to assess if national disease databases on TB and HIV are adequate sources to provide this information.

    Methods A two way capture-recapture analysis to assess the completeness of the registers, and to obtain the prevalence of TB-HIV co-infection in the Netherlands in the years 2002-2012.

    Results HIV testing was performed in less than 50% of the patients with TB. Of the 932 TB-HIV infected patients, just 293 (31.4%) were registered in both registers. Under-reporting of TB-HIV co-infection ranged from 50% to 70% in the national TB register, and from 31% to 37% in the HIV database. Prevalence of TB-HIV co-infection in the Netherlands in 2012 was 7.1% (95% CI 6.0% to 8.3%), which was more than double of the prevalence estimated from the national TB database.

    Conclusions TB-HIV co-infection is markedly under-reported in national disease databases. There is an urgent need for improved registration and preferably a routine data exchange between the two surveillance systems.

    Originele taal-2English
    Pagina's (van-tot)556-560
    Aantal pagina's5
    TijdschriftJournal of Epidemiology and Community Health
    Nummer van het tijdschrift6
    StatusPublished - jun-2016

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