Technical Note: 4D cone-beam CT reconstruction from sparse-view CBCT data for daily motion assessment in pencil beam scanned proton therapy (PBS-PT)

Lydia Otter, den, Kuanling Chen, Guillaume Janssens, Artürs Meijers, Stefan Both, J.A. Langendijk, L. R. Rosen, Hsinshun T. Wu, Antje Knopf

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7 Citaten (Scopus)
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Purpose: The number of pencil beam scanned proton therapy (PBS-PT) facilities equipped with
cone-beam computed tomography (CBCT) imaging treating thoracic indications is constantly rising.
To enable daily internal motion monitoring during PBS-PT treatments of thoracic tumors, we assess
the performance of Motion-Aware RecOnstructiOn method using Spatial and Temporal Regularization
(MA-ROOSTER) four-dimensional CBCT (4DCBCT) reconstruction for sparse-view CBCT
data and a realistic data set of patients treated with proton therapy.
Methods: Daily CBCT projection data for nine non-small cell lung cancer (NSCLC) patients and
one SCLC patient were acquired at a proton gantry system (IBA Proteus® One). Four-dimensional
CBCT images were reconstructed applying the MA-ROOSTER and the conventional phase-correlated
Feldkamp-Davis-Kress (PC-FDK) method. Image quality was assessed by visual inspection,
contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), and the structural similarity index measure
(SSIM). Furthermore, gross tumor volume (GTV) centroid motion amplitudes were evaluated.
Results: Image quality for the 4DCBCT reconstructions using MA-ROOSTER was superior to the
PC-FDK reconstructions and close to FDK images (median CNR: 1.23 [PC-FDK], 1.98 [MA-ROOSTER],
and 1.98 [FDK]; median SNR: 2.56 [PC-FDK], 4.76 [MA-ROOSTER], and 5.02 [FDK]; median
SSIM: 0.18 [PC-FDK vs FDK], 0.31 [MA-ROOSTER vs FDK]). The improved image quality of
MA-ROOSTER facilitated GTV contour warping and realistic motion monitoring for most of the
Conclusion: MA-ROOSTER based 4DCBCTs performed well in terms of image quality and appear
to be promising for daily internal motion monitoring in PBS-PT treatments of (N)SCLC patients.
Originele taal-2English
Pagina's (van-tot)6381-6387
Aantal pagina's7
TijdschriftMedical Physics
Nummer van het tijdschrift12
Vroegere onlinedatum25-okt-2020
StatusPublished - dec-2020

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