Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer's disease

Nelleke Tolboom; Maqsood Yaqub; Ronald Boellaard; Gert Luurtsema; Albert D. Windhorst; Philip Scheltens; Adriaan A. Lammertsma; Bart N. M. van Berckel

doi:10.1007/s00259-009-1129-6

Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer's disease

Nelleke Tolboom^*, Maqsood Yaqub, Ronald Boellaard, Gert Luurtsema, Albert D. Windhorst, Philip Scheltens, Adriaan A. Lammertsma, Bart N. M. van Berckel

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput › Academic › peer review

57 Citaten (Scopus)

Samenvatting

Purpose The aim of this study was to assess the test-retest variability of [(11)C] PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.

Methods [(11)C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.

Results Test-retest variability was best (similar to 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values (similar to 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.

Conclusion Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [(11)C]PIB PET studies.

Originele taal-2	English
Pagina's (van-tot)	1629-1638
Aantal pagina's	10
Tijdschrift	European Journal of Nuclear Medicine and Molecular Imaging
Volume	36
Nummer van het tijdschrift	10
DOI's	https://doi.org/10.1007/s00259-009-1129-6
Status	Published - okt.-2009
Extern gepubliceerd	Ja

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title = "Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer's disease",

abstract = "Purpose The aim of this study was to assess the test-retest variability of [(11)C] PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.Methods [(11)C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.Results Test-retest variability was best (similar to 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values (similar to 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.Conclusion Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [(11)C]PIB PET studies.",

keywords = "Pittsburgh compound B, PIB, Arterial sampling, Cerebellum, Parametric images, Amyloid, PET, PITTSBURGH COMPOUND-B, REFERENCE TISSUE MODEL, AMYLOID DEPOSITION, SENILE PLAQUES, HUMAN BRAIN, BINDING, NEURORECEPTOR, CEREBELLUM, RECEPTOR",

author = "Nelleke Tolboom and Maqsood Yaqub and Ronald Boellaard and Gert Luurtsema and Windhorst, {Albert D.} and Philip Scheltens and Lammertsma, {Adriaan A.} and {van Berckel}, {Bart N. M.}",

year = "2009",

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doi = "10.1007/s00259-009-1129-6",

language = "English",

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pages = "1629--1638",

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T1 - Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer's disease

AU - Tolboom, Nelleke

AU - Yaqub, Maqsood

AU - Boellaard, Ronald

AU - Luurtsema, Gert

AU - Windhorst, Albert D.

AU - Scheltens, Philip

AU - Lammertsma, Adriaan A.

AU - van Berckel, Bart N. M.

PY - 2009/10

Y1 - 2009/10

N2 - Purpose The aim of this study was to assess the test-retest variability of [(11)C] PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.Methods [(11)C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.Results Test-retest variability was best (similar to 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values (similar to 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.Conclusion Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [(11)C]PIB PET studies.

AB - Purpose The aim of this study was to assess the test-retest variability of [(11)C] PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.Methods [(11)C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.Results Test-retest variability was best (similar to 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values (similar to 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.Conclusion Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [(11)C]PIB PET studies.

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KW - Arterial sampling

KW - Cerebellum

KW - Parametric images

KW - Amyloid

KW - PET

KW - PITTSBURGH COMPOUND-B

KW - REFERENCE TISSUE MODEL

KW - AMYLOID DEPOSITION

KW - SENILE PLAQUES

KW - HUMAN BRAIN

KW - BINDING

KW - NEURORECEPTOR

KW - CEREBELLUM

KW - RECEPTOR

U2 - 10.1007/s00259-009-1129-6

DO - 10.1007/s00259-009-1129-6

M3 - Article

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JO - European Journal of Nuclear Medicine and Molecular Imaging

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