Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer's disease

Nelleke Tolboom*, Maqsood Yaqub, Ronald Boellaard, Gert Luurtsema, Albert D. Windhorst, Philip Scheltens, Adriaan A. Lammertsma, Bart N. M. van Berckel

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

57 Citaten (Scopus)


Purpose The aim of this study was to assess the test-retest variability of [(11)C] PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.

Methods [(11)C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.

Results Test-retest variability was best (similar to 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values (similar to 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.

Conclusion Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [(11)C]PIB PET studies.

Originele taal-2English
Pagina's (van-tot)1629-1638
Aantal pagina's10
TijdschriftEuropean Journal of Nuclear Medicine and Molecular Imaging
Nummer van het tijdschrift10
StatusPublished - okt.-2009
Extern gepubliceerdJa

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