The association between concomitant use of serotonergic antidepressants and lithium-induced polyuria. A multicenter medical chart review study

I. Wilting, A. C. G. Egberts*, K. L. L. Movig, J. H. M. van Laarhoven, E. R. Heerdink, W. A. Nolen

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

4 Citaten (Scopus)

Samenvatting

Background: A previous Study aimed at revealing the prevalence and determinants Of lithium induced polyuria Suggested an increased risk of polyuria (urine volume >= 3L/24h) in those using serotonergic antidepressants next to lithium.

Objective: The objective of our study was to re-evaluate this secondary finding in another study population.

Methods: We performed a multicenter medical chart review study in patients using lithium in whom a 24-hour urine volume had been determined.

Results: We included 116 patients, twelve (26 %) of the 46 patients with polyuria used serotonergic antidepressants compared to ten (14%) of the 70 patients without polyuria. We found an increased risk of polyuria in lithium users concurrently using serotonergic antidepressants (odds ratio 2.86; 95 % confidence interval 1.00-8.21), adjusted for age, gender, use of antiepileptics and thyreomimetics.

Conclusion: Our results Confirm the previous secondary finding of an increased risk of polyuria in patients using serotonergic antidepressants next to lithium. Physicians should take this into account when evaluating polytiria in patients using lithium and when choosing an antidepressant in patients using lithium.

Originele taal-2English
Pagina's (van-tot)129-133
Aantal pagina's5
TijdschriftPharmacopsychiatry
Volume41
Nummer van het tijdschrift4
DOI's
StatusPublished - jul-2008

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