The effect of chronic selective serotonin reuptake inhibitor treatment on serotonin(1B) receptor sensitivity and HPA axis activity

M.E. Jongsma*, F.J Bosker, T.I.F.H. Cremers, B.H.C. Westerink, J.A. Den Boer

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

32 Citaten (Scopus)


The authors have investigated 5-HT1B receptor function in prefrontal cortex and dorsal hippocampus as well as the HPA axis response after subchronic (24 h) and chronic (15 days) treatment with the SSRI citalopram. All experiments were carried out in presence of citalopram to prevent rapid resensitization of the 5-HT1B receptors. Moreover, this more closely resembles the clinical situation. The concentration of citalopram was measured in both brain areas to ensure comparable levels in the different treatment groups. Using microdialysis, the authors found that under those conditions the effect of the 5-HT1B receptor antagonists SB 224289 and the mixed 5-HT1B/1D receptor antagonist GR 127935 on extracellular levels of 5-HT was unaltered by duration of treatment. Basal levels of 5-HT, however, were increased in the dorsal hippocampus following chronic treatment. In addition, plasma levels of the catecholamines adrenaline and noradrenaline and the HPA axis hormones ACTH and corticosterone were all decreased after chronic treatment. (C0 2005 Elsevier Inc. All rights reserved.

Originele taal-2English
Pagina's (van-tot)738-744
Aantal pagina's7
TijdschriftProgress in Neuro-Psychopharmacology & Biological Psychiatry
Nummer van het tijdschrift5
StatusPublished - jun.-2005

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