The Emerging Role of Viability Testing During Liver Machine Perfusion

Isabel M. A. Bruggenwirth, Otto B. van Leeuwen, Robert J. Porte, Paulo N. Martins*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

14 Citaten (Scopus)
54 Downloads (Pure)


The transplant community continues to be challenged by the disparity between the need for liver transplantation and the shortage of suitable donor organs. At the same time, the number of unused donor livers continues to increase, most likely attributed to the worsening quality of these organs. To date, there is no reliable marker of liver graft viability that can predict good posttransplant outcomes. Ex situ machine perfusion offers additional data to assess the viability of donor livers before transplantation. Hence, livers initially considered unsuitable for transplantation can be assessed during machine perfusion in terms of appearance and consistency, hemodynamics, and metabolic and excretory function. In addition, postoperative complications such as primary nonfunction or posttransplant cholangiopathy may be predicted and avoided. A variety of viability criteria have been used in machine perfusion, and to date there is no widely accepted composition of criteria for clinical use. This review discusses potential viability markers for hepatobiliary function during machine perfusion, describes current limitations, and provides future recommendations for the use of viability criteria in clinical liver transplantation.

Originele taal-2English
Pagina's (van-tot)876-886
Aantal pagina's11
TijdschriftLiver Transplantation
Nummer van het tijdschrift5
Vroegere onlinedatum24-jun.-2021
StatusPublished - 1-mei-2022

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