The Endothelium as a Target for Anti-Atherogenic Therapy: A Focus on the Epigenetic Enzymes EZH2 and SIRT1

Jolien Fledderus, Byambasuren Vanchin, Marianne G Rots, Guido Krenning*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

17 Citaten (Scopus)
83 Downloads (Pure)


Endothelial cell inflammatory activation and dysfunction are key events in the pathophysiology of atherosclerosis, and are associated with an elevated risk of cardiovascular events. Yet, therapies specifically targeting the endothelium and atherosclerosis are lacking. Here, we review how endothelial behaviour affects atherogenesis and pose that the endothelium may be an efficacious cellular target for antiatherogenic therapies. We discuss the contribution of endothelial inflammatory activation and dysfunction to atherogenesis and postulate that the dysregulation of specific epigenetic enzymes, EZH2 and SIRT1, aggravate endothelial dysfunction in a pleiotropic fashion. Moreover, we propose that commercially available drugs are available to clinically explore this postulation.

Originele taal-2English
Aantal pagina's21
TijdschriftJournal of personalized medicine
Nummer van het tijdschrift2
StatusPublished - 5-feb.-2021

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