TY - JOUR
T1 - The epidemiology of neuromuscular disorders
T2 - Age at onset and gender in the Netherlands
AU - Deenen, Johanna C. W.
AU - van Doorn, Pieter A.
AU - Faber, Catharina G.
AU - van der Kooi, Anneke J.
AU - Kuks, Jan B. M.
AU - Notermans, Nicolette C.
AU - Visser, Leo H.
AU - Horlings, Corinne G. C.
AU - Verschuuren, Jan J. G. M.
AU - Verbeek, Andre L. M.
AU - van Engelen, Baziel G. M.
PY - 2016/7
Y1 - 2016/7
N2 - Based on approximately eight years of data collection with the nationwide Computer Registry of All Myopathies and Polyneuropathies (CRAMP) in the Netherlands, recent epidemiologic information for thirty neuromuscular disorders is presented. This overview includes age and gender data for a number of neuromuscular disorders that are either relatively frequently seen in the neuromuscular clinic, or have a particular phenotype. Since 2004, over 20,000 individuals with a neuromuscular disorder were registered in CRAMP; 56% men and 44% women. The number per diagnosis varied from nine persons with Emery Dreifuss muscular dystrophy to 2057 persons with amyotrophic lateral sclerosis. Proportions of men ranged from 38% with post-polio syndrome to 68% with progressive spinal muscular atrophy, excluding X-chromosome linked disorders. Inclusion body myositis showed the highest median age at diagnosis of 70 years. These data may be helpful in the diagnostic process in clinical practice and trial readiness. (C) 2016 Elsevier B.V. All rights reserved.
AB - Based on approximately eight years of data collection with the nationwide Computer Registry of All Myopathies and Polyneuropathies (CRAMP) in the Netherlands, recent epidemiologic information for thirty neuromuscular disorders is presented. This overview includes age and gender data for a number of neuromuscular disorders that are either relatively frequently seen in the neuromuscular clinic, or have a particular phenotype. Since 2004, over 20,000 individuals with a neuromuscular disorder were registered in CRAMP; 56% men and 44% women. The number per diagnosis varied from nine persons with Emery Dreifuss muscular dystrophy to 2057 persons with amyotrophic lateral sclerosis. Proportions of men ranged from 38% with post-polio syndrome to 68% with progressive spinal muscular atrophy, excluding X-chromosome linked disorders. Inclusion body myositis showed the highest median age at diagnosis of 70 years. These data may be helpful in the diagnostic process in clinical practice and trial readiness. (C) 2016 Elsevier B.V. All rights reserved.
KW - Neuromuscular disorders
KW - Neuromuscular diseases
KW - Epidemiology
KW - Age
KW - Gender
U2 - 10.1016/j.nmd.2016.04.011
DO - 10.1016/j.nmd.2016.04.011
M3 - Article
SN - 0960-8966
VL - 26
SP - 447
EP - 452
JO - Neuromuscular disorders
JF - Neuromuscular disorders
IS - 7
ER -