THE EVOLUTION OF IMMUNE MEMORY AND GERMINAL-CENTERS

MH NAHM*, FGM KROESE, JW HOFFMANN

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

29 Citaten (Scopus)

Samenvatting

Antibody responses in homoiothermic and poikilothermic vertebrates are significantly different in their heterogeneity and affinity range, and in the speed of the secondary response following repeated antigenic stimulation. This article presents the hypothesis that the evolutionary development of unique lymphoid structures, the germinal centers, in combination with the development of a distinct B-cell lineage, is a determining feature of these differences.

Originele taal-2English
Pagina's (van-tot)438-441
Aantal pagina's4
TijdschriftImmunology Today
Volume13
Nummer van het tijdschrift11
StatusPublished - nov-1992

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